Publications

P.P. Mapfumo, J. I. Solomun, F. Becker, E. Moek, M. N. Leiske, L. K. Rudolph, J. C. Brendel, A. Traeger, “Vitamin B3 Containing Polymers for Nanodelivery“,Macromol Biosci 2024, e2400002.

De Breuck, M. Streiber, M. Ringleb, D. Schröder, N. Herzog, U.S. Schubert, S. Zechel, A. Traeger, M. Leiske, „Amino-acid-derived anionic polyacrylamides with tailored hydrophobicity – physicochemical properties and cellular interactions“, ACS Polymers Au 2024, accepted

Leer, L. S. Reichel, M. Wilhelmi, J. C. Brendel, A. Traeger, “Tailoring Gene Transfer Efficacy through the Arrangement of Cationic and Anionic Blocks in Triblock Copolymer Micelles“, ACS Macro. Letters 2024, 13, 158-165

P.P. Mapfumo, L. S. Reichel, S. Hoeppener, A. Traeger, “Improving Gene Delivery: Synergy between Alkyl Chain Length and Lipoic Acid for PDMAEMA Hydrophobic Copolymers“,Macromol. Rapid Commun. 2024, n/a, 2300649

Leer, L. S. Reichel, J. Kimmig, F. Richter, S. Hoeppener, J. C. Brendel, S. Zechel, U. S. Schubert, A. Traeger, “Optimization of Mixed Micelles Based on Oppositely Charged Block Copolymers by Machine Learning for Application in Gene Delivery“, Small 2024, 20, 2306116

M. Peschel, L. S. Reichel, T. Hoffmann, C. Enzensberger, U. S. Schubert, A. Traeger, M. Gottschaldt, “Modification of branched poly(ethylene imine) with D-fructose for selective delivery of siRNA into human breast cancer cells”, Macromol. Biosci. 2023, 2300135

Hausig-Punke, G. Dekevic, F. H. Sobotta, J. I. Solomun, F. Richter, D. Salzig, A. Traeger, J. C. Brendel, “Efficient transfection via an unexpected mechanism by near-neutral polypiperazines with tailored response to endosomal pH”, Macromol. Biosci.  2023, 2200517

Klemm, J. I. Solomun, M. Rodewald, M. T. Kuchenbrod, V. G. Hänsch, F. Richter, J. Popp, C. Hertweck, S. Hoeppener, C. Bonduelle, S. Lecommandoux, A. Traeger, S. Schubert “Polyplex Surfing as Efficient Gene Delivery Mechanism of Tailored Amphiphilic Polypeptides” Biomacromolecules 2022, 23, 4718-4733

I. Solomun, L. Martin, P. Mapfumo, E. Moek, E. Amro, F. Becker, S. Tuempel, S. Hoeppener, K. L. Rudolph, A. Traeger, “PH-Sensitive Packaging of Cationic Particles by an Anionic Block Copolymer Shell”, J. Nanobiotechnology 2022, 20, 336

Hausig-Punke, F. Richter, M. Hoernke, J. C. Brendel, A. Traeger, “Tracking the Endosomal Escape: A Closer Look at Calcein and Related Reporters”, Macromol. Biosci.  2022, n/a, 2200167

Cinar, J. I. Solomun, P. Mapfumo, A. Traeger, I. Nischang, “Nanoparticle sizing in the field of nanomedicine: Power of an analytical ultracentrifuge”, Anal. Chim. Acta 2022, 1205, 339741

T. Kammann, J. Hoff, I. Yildirim, B. Shkodra, T. Müller, C. Weber, M. H. Gräler, U. A. Maus, J. C. Paton, M. Singer, A. Traeger, U. S. Schubert, M. Bauer, A. T. Press, “Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival”, Metabolites 2021, 11. DOI: 10.3390/metabo11120821

C. Chen, F. Richter, J. Zhang, C. Guerrero-Sanchez, A. Traeger. U. S. Schubert, A. Feng, S. H. Thang, “Synthesis of functional miktoarm star polymers in an automated parallel Synthesizer”, Eur. Polym. J. 2021, accepted. DOI: 10.1016/j.eurpolymj.2021.110777

K. Leer, G. Cinar, J. I. Solomun, L. Martin, I. Nischang, A. Traeger, “Core-crosslinked, temperature- and pH-responsive micelles: Design, physicochemical characterization, and gene delivery application”, Nanoscale 2021, DOI: 10.1039/D1NR04223H

F. Richter, K. Leer, L. Martin, P. Mapfumo, J. I. Solomun, M. T. Kuchenbrod,S. Hoeppener, J. C. Brendel, A. Traeger, “The Impact of Anionic Polymers on Gene Delivery: How Composition and Assembly Help Evading the Toxicity-Efficiency Dilemma”, J. Nanobiotechnology 2021, DOI : 10.1186/s12951-021-00994-2.

P. Klemm, M. Behnke, J. I. Solomun, C. Bonduelle, S. Lecommandoux, A. Traeger, S. Schubert, “Self-assembled PEGylated Amphiphilic Polypeptides for Gene Transfection”, J. Mater. Chem. B, 2021, DOI: 10.1039/D1TB01495A

F. Hausig, F. H. Sobotta, F. Richter, D. O. Harz, A. Traeger, J. C. Brendel, “Correlation between Protonation of Tailor-Made Polypiperazines and Endosomal Escape for Cytosolic Protein Delivery”, ACS Appl. Mater. Interfaces 2021, DOI: 10.1021/acsami.1c00829

F. Richter, P. Mapfumo, L. Martin, J. I. Solomun, F. Hausig, J. J. Frietsch, T. Ernst, S. Hoeppener, J. C. Brendel, A. Traeger, “Improved Gene Delivery to K-562 Leukemia Cells by Lipoic Acid Modified Block Copolymer Micelles”, J. Nanobiotechnology 2021, 19, 70

J. I. Solomun, G. Cinar, P. Mapfumo, F. Richter, E. Moek, F. Hausig, L. Martin, S. Hoeppener, I. Nischang, A. Traeger, “Solely Aqueous Formulation of Hydrophobic Cationic Polymers for Efficient Gene Delivery”, Int. J. Pharm. 2021, 593, 120080

B. Shkodra, A. T. Press, A. Vollrath, I. Nischang, S. Schubert, S. Hoeppener, D. Haas, C. Enzensperger, M. Lehmann, P. Babic, K. J. Benecke, A. Traeger, M. Bauer, U. S. Schubert, “Formulation of Liver-Specific PLGA-DY-635 Nanoparticles Loaded with the Protein Kinase C Inhibitor Bisindolylmaleimide I”, Pharmaceutics 2020, 12, 1110.

Richter, L. Martin, K. Leer, E. Moek, F. Hausig, J. C. Brendel, A. Traeger, “Tuning of Endosomal Escape and Gene Expression by Functional Groups, Molecular Weight and Transfection Medium: A Structure–Activity Relationship Study“, J. Mat. Chem. B 2020, 8, 5026-5041.

C. Chen, F. Richter, C. Guerrero-Sanchez, A. Traeger, U. S. Schubert, A. Feng, S. H. Thang, “Cell-Penetrating, Peptide-Based Raft Agent for Constructing Penetration Enhancers“, ACS Macro Lett. 2020, 260-265.

A. Traeger, S. Voelker, B. Shkodra-Pula, C. Kretzer, S. Schubert, M. Gottschaldt, U. S. Schubert, O. Werz, “Improved Bioactivity of the Natural Product 5-Lipoxygenase Inhibitor Hyperforin by Encapsulation into Polymeric Nanoparticles“, Mol. Pharm. 2020, 17, 810-816.

B. Shkodra-Pula, C. Grune, A. Traeger, A. Vollrath, S. Schubert, D. Fischer, U. S. Schubert, “Effect of Surfactant on the Size and Stability of Plga Nanoparticles Encapsulating a Protein Kinase C Inhibitor“, Int. J. Pharm. 2019, 566, 756-764.

A.-K. Trützschler, T. Bus, M. Sahn, A. Traeger, C. Weber, U. S. Schubert, “The Power of Shielding: Low Toxicity and High Transfection Performance of Cationic Graft Copolymers Containing Poly(2-Oxazoline) Side Chains“, Biomacromolecules 2018, 19, 2759-2771.

A.-K. Trützschler, T. Bus, M. Reifarth, J. C. Brendel, S. Hoeppener, A. Traeger, U. S. Schubert, “Beyond Gene Transfection with Methacrylate-Based Polyplexes—the Influence of the Amino Substitution Pattern“, Bioconjug. Chem. 2018, 29, 2181-2194

M. N. Leiske, F. H. Sobotta, F. Richter, S. Hoeppener, J. C. Brendel, A. Traeger, U. S. Schubert, “How to Tune the Gene Delivery and Biocompatibility of Poly(2-(4-Aminobutyl)-2-Oxazoline) by Self- and Coassembly“, Biomacromolecules 2018, 19, 748-760.

D. Hertz, M. N. Leiske, T. Wloka, A. Traeger, M. Hartlieb, M. M. Kessels, S. Schubert, B. Qualmann, U. S. Schubert, “Comparison of Random and Gradient Amino Functionalized Poly(2-Oxazoline)S: Can the Transfection Efficiency Be Tuned by the Macromolecular Structure?“, J. Polym. Sci. Pol. Chem. 2018, 56, 1210-1224.

C. Englert, I. Nischang, C. Bader, P. Borchers, J. Alex, M. Pröhl, M. Hentschel, M. Hartlieb, A. Traeger, G. Pohnert, S. Schubert, M. Gottschaldt, U. S. Schubert, “Lichtgesteuerte Freisetzung Von Chemikalien Aus Polymeren Nano- Und Mikropartikelbehältern“, Angew. Chem. 2018, 130, 2504-2508.

C. Englert, I. Nischang, C. Bader, P. Borchers, J. Alex, M. Prohl, M. Hentschel, M. Hartlieb, A. Traeger, G. Pohnert, S. Schubert, M. Gottschaldt, U. S. Schubert, “Photocontrolled Release of Chemicals from Nano- and Microparticle Containers“, Angew. Chem. Int. Ed. Engl. 2018, 57, 2479-2482.

T. Bus, A. Traeger, U. S. Schubert, “The Great Escape: How Cationic Polyplexes Overcome the Endosomal Barrier“, Journal of Materials Chemistry B 2018, 6, 6904-6918.

T. Yildirim, A. Traeger, P. Sungur, S. Hoeppener, C. Kellner, I. Yildirim, D. Pretzel, S. Schubert, U. S. Schubert, “Polymersomes with Endosomal pH-Induced Vesicle-to-Micelle Morphology Transition and a Potential Application for Controlled Doxorubicin Delivery“, Biomacromolecules 2017, 18, 3280-3290.

M. Prohl, P. D. Moser, J. A. Czaplewska, P. Hoffmann, T. Bus, A. Traeger, H. Goerls, U. S. Schubert, M. Gottschaldt, “Synthesis of D-Fructose Conjugated Ligands Via C6 and C1 and Their Corresponding [Ru(Bpy)2(L)]Cl2 Complexes“, Carbohydr. Res. 2017, 446-447, 19-27.

I. Perevyazko, A.-K. Trützschler, A. Gubarev, E. Lebedeva, A. Traeger, N. Tsvetkov, U. S. Schubert, “Absolute Characteristics and Conformation of Cationic Polymers by Hydrodynamic Approaches: Poly(AEMA-co-MAEMA-co-DMAEMA)stat Copolymers“, Eur. Polym. J. 2017, 97, 347-355.

I. Perevyazko, A.-K. Trützschler, A. Gubarev, E. Lebedeva, A. Traeger, U. S. Schubert, N. Tsvetkov, “Molecular and Structural Analysis Via Hydrodynamic Methods: Cationic Poly(2-Aminoethyl-Methacrylate)s“, Polymer 2017, 131, 252-262.

M. N. Leiske, A.-K. Trutzschler, S. Armoneit, P. Sungur, S. Hoeppener, M. Lehmann, A. Traeger, U. S. Schubert, “Mission Impoxable - or the Unknown Utilization of Non-Toxic Poly(2-Oxazoline)S as Cryoprotectants and Surfactants at the Same Time“, J. Mater. Chem. B 2017.

C. Englert, M. Prohl, J. A. Czaplewska, C. Fritzsche, E. Preussger, U. S. Schubert, A. Traeger, M. Gottschaldt, “D-Fructose-Decorated Poly(Ethylene Imine) for Human Breast Cancer Cell Targeting“, Macromol. Biosci. 2017, 17.

T. Bus, C. Englert, M. Reifarth, P. Borchers, M. Hartlieb, A. Vollrath, S. Hoeppener, A. Traeger, U. S. Schubert, “3rd Generation Poly(Ethylene Imine)S for Gene Delivery“, J. Mater. Chem. B 2017, 5, 1258-1274.

T. Yildirim, A. Traeger, E. Preussger, S. Stumpf, C. Fritzsche, S. Hoeppener, S. Schubert, U. S. Schubert, “Dual Responsive Nanoparticles from a Raft Copolymer Library for the Controlled Delivery of Doxorubicin“, Macromolecules 2016, 49, 3856-3868.

I. Yildirim, T. Bus, M. Sahn, T. Yildirim, D. Kalden, S. Hoeppener, A. Traeger, M. Westerhausen, C. Weber, U. S. Schubert, “Fluorescent Amphiphilic Heterografted Comb Polymers Comprising Biocompatible PLA and PEtOx Side Chains“, Polym. Chem. 2016, 7, 6064-6074.

M. Pröhl, T. Bus, J. A. Czaplewska, A. Traeger, M. Deicke, H. Weiss, W. Weigand, U. S. Schubert, M. Gottschaldt, “Synthesis and in Vitro Toxicity of D-Glucose and D-Fructose Conjugated Curcumin–Ruthenium Complexes“, Eur. J. Inorg. Chem. 2016, 2016, 5197-5204.

C. Englert, A. K. Trutzschler, M. Raasch, T. Bus, P. Borchers, A. S. Mosig, A. Traeger, U. S. Schubert, “Crossing the Blood-Brain Barrier: Glutathione-Conjugated Poly(Ethylene Imine) for Gene Delivery“, J. Control. Release 2016, 241, 1-14.

T. Yildirim, A. C. Rinkenauer, C. Weber, A. Traeger, S. Schubert, U. S. Schubert, “RAFT Made Methacrylate Copolymers for Reversible pH-Responsive Nanoparticles“, J. Polym. Sci. A 2015, 53, 2711-2721.

M. Wagner, C. Pietsch, A. Kerth, A. Traeger, U. S. Schubert, “Physicochemical Characterization of the Thermo-Induced Self-Assembly of Thermo-Responsive PDMAEMA-b-PDEGMA Copolymers“, J. Polym. Sci. A 2015, 53, 924-935.

A. C. Rinkenauer, L. Tauhardt, F. Wendler, K. Kempe, M. Gottschaldt, A. Traeger, U. S. Schubert, “A Cationic Poly(2-Oxazoline) with High in vitro Transfection Efficiency Identified by a Library Approach“, Macromol. Biosci. 2015, 15, 414-425.

A. C. Rinkenauer, S. Schubert, A. Traeger, U. S. Schubert, “The Influence of Polymer Architecture on in vitro pDNA Transfection“, J. Mater. Chem. B 2015, 3, 7477-7493.

A. C. Rinkenauer, A. T. Press, M. Raasch, C. Pietsch, S. Schweizer, S. Schworer, K. L. Rudolph, A. Mosig, M. Bauer, A. Traeger, U. S. Schubert, “Comparison of the Uptake of Methacrylate-Based Nanoparticles in Static and Dynamic in vitro Systems as Well as in vivo“, J. Control. Release 2015, 216, 158-168.

M. Wagner, C. Pietsch, L. Tauhardt, A. Schallon, U. S. Schubert, “Characterization of Cationic Polymers by Asymmetric Flow Field-Flow Fractionation and Multi-Angle Light Scattering-a Comparison with Traditional Techniques“, J. Chromatogr. A 2014, 1325, 195-203.

M. Wagner, S. Holzschuh, A. Traeger, A. Fahr, U. S. Schubert, “Asymmetric Flow Field-Flow Fractionation in the Field of Nanomedicine“, Anal. Chem. 2014, 86, 5201-5210.

M. Wagner, M. J. Barthel, R. R. A. Freund, S. Hoeppener, A. Traeger, F. H. Schacher, U. S. Schubert, “Solution Self-Assembly of Poly(Ethylene Oxide)-Block-Poly(Furfuryl Glycidyl Ether)-Block-Poly(Allyl Glycidyl Ether) Based Triblock Terpolymers: A Field-Flow Fractionation Study“, Polym. Chem. 2014, 5, 6943-6956.

A. T. Press, A. Traeger, C. Pietsch, A. Mosig, M. Wagner, M. G. Clemens, N. Jbeily, N. Koch, M. Gottschaldt, N. Beziere, V. Ermolayev, V. Ntziachristos, J. Popp, M. M. Kessels, B. Qualmann, U. S. Schubert, M. Bauer, “Cell Type-Specific Delivery of Short Interfering Rnas by Dye-Functionalised Theranostic Nanoparticles“, Nat. Commun. 2014, 5, 5565.

M. J. Barthel, A. C. Rinkenauer, M. Wagner, U. Mansfeld, S. Hoeppener, J. A. Czaplewska, M. Gottschaldt, A. Trager, F. H. Schacher, U. S. Schubert, “Small but Powerful: Co-Assembly of Polyether-Based Triblock Terpolymers into Sub-30 nm Micelles and Synergistic Effects on Cellular Interactions“, Biomacromolecules 2014, 15, 2426-2439.

M. Wagner, A. C. Rinkenauer, A. Schallon, U. S. Schubert, “Opposites Attract: Influence of the Molar Mass of Branched Poly(Ethylene Imine) on Biophysical Characteristics of siRNA-Based Polyplexese“, RSC Adv. 2013, 3, 12774-12785.

A. Vollrath, A. Schallon, C. Pietsch, S. Schubert, T. Nomoto, Y. Matsumoto, K. Kataoka, U. S. Schubert, “A Toolbox of Differently Sized and Labeled PMMA Nanoparticles for Cellular Uptake Investigations“, Soft Matter 2013, 9, 99-108.

A. C. Rinkenauer, A. Vollrath, A. Schallon, L. Tauhardt, K. Kempe, S. Schubert, D. Fischer, U. S. Schubert, “Parallel Hightthroughput Screening of Polymer Vectors for Nonviral Gene Delivery: Evaluation of Structure–Property Relationships of Transfection“, ACS Comb. Sci. 2013, 15, 475-482.

A. C. Rinkenauer, A. Schallon, U. Günther, M. Wagner, E. Betthausen, U. S. Schubert, F. H. Schacher, “A Paradigm Change: Efficient Transfection of Human Leukemia Cells by Stimuli-Responsive Multicompartment Micelles“, ACS Nano 2013, 7, 9621-9631.

K. Knop, D. Pretzel, A. Urbanek, T. Rudolph, D. H. Scharf, A. Schallon, M. Wagner, S. Schubert, M. Kiehntopf, A. A. Brakhage, F. H. Schacher, U. S. Schubert, “Star-Shaped Drug Carriers for Doxorubicin with POEGMA and POEtOxMA Brush-Like Shells: A Structural, Physical, and Biological Comparison“, Biomacromolecules 2013, 14, 2536-2548.

A. Schallon, C. V. Synatschke, V. Jerome, A. H. E. Müller, R. Freitag, “Nanoparticulate Nonviral Agent for the Effective Delivery of pDNA and siRNA to Cifferentiated Cells and Primary Human T Lymphocytes“, Biomacromolecules 2012, 13, 3463-3474.

A. P. Majewski, A. Schallon, V. Jerome, R. Freitag, A. H. E. Müller, H. Schmalz, “Dual-Responsive Magnetic Core-Shell Nanoparticles for Nonviral Gene Delivery and Cell Separation“, Biomacromolecules 2012, 13, 857-866.

C. V. Synatschke, A. Schallon, V. Jerome, R. Freitag, A. H. E. Müller, “Influence of Polymer Architecture and Molecular Weight of Poly(2-(Dimethylamino)Ethyl Methacrylate) Polycations on Transfection Efficiency and Cell Viability in Gene Delivery“, Biomacromolecules 2011, 12, 4247-4255.

A. Schallon, C. V. Synatschke, D. V. Pergushov, V. Jerome, A. H. E. Müller, R. Freitag, “DNA Melting Temperature Assay for Assessing the Stability of DNA Polyplexes Tntended for Nonviral Gene Delivery“, Langmuir 2011, 27, 12042-12051.

A. Pfaff, A. Schallon, T. M. Ruhland, A. P. Majewski, H. Schmalz, R. Freitag, A. H. E. Müller, “Magnetic and Fluorescent Glycopolymer Hybrid Nanoparticles for Intranuclear Optical Imaging“, Biomacromolecules 2011, 12, 3805-3811.

A. Schallon, V. Jerome, A. Walther, C. V. Synatschke, A. H. E. Müller, R. Freitag, “Performance of Three PDMAEMA-Based Polycation Architectures as Gene Delivery Agents in Comparison to Linear and Branched PEI“, React. Funct. Polym. 2010, 70, 1-10.

M. Müllner, A. Schallon, A. Walther, R. Freitag, A. H. E. Müller, “Clickable, Biocompatible, and Fluorescent Hybrid Nanoparticles for Intracellular Delivery and Optical Imaging“, Biomacromolecules 2010, 11, 390-396.

V. Jerome, A. Heider, A. Schallon, R. Freitag, “Exhaustive in Vivo Labelling of Plasmid DNA with BrdU for Intracellular Detection in Non-Viral Transfection of Mammalian Cells“, Biotechnol. J. 2009, 4, 1479-1487.