[54]
T. Kammann, J. Hoff, I. Yildirim, B. Shkodra, T. Müller, C. Weber, M. H. Gräler, U. A. Maus, J. C. Paton, M. Singer, A. Traeger, U. S. Schubert, M. Bauer, A. T. Press, “Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival”, Metabolites 2021, 11. DOI: 10.3390/metabo11120821
[53]
C. Chen, F. Richter, J. Zhang, C. Guerrero-Sanchez, A. Traeger. U. S. Schubert, A. Feng, S. H. Thang, “Synthesis of functional miktoarm star polymers in an automated parallel Synthesizer”, Eur. Polym. J. 2021, accepted. DOI: 10.1016/j.eurpolymj.2021.110777
[52]
K. Leer, G. Cinar, J. I. Solomun, L. Martin, I. Nischang, A. Traeger, “Core-crosslinked, temperature- and pH-responsive micelles: Design, physicochemical characterization, and gene delivery application”, Nanoscale 2021, DOI: 10.1039/D1NR04223H
[51]
F. Richter, K. Leer, L. Martin, P. Mapfumo, J. I. Solomun, M. T. Kuchenbrod,S. Hoeppener, J. C. Brendel, A. Traeger, “The Impact of Anionic Polymers on Gene Delivery: How Composition and Assembly Help Evading the Toxicity-Efficiency Dilemma”, J. Nanobiotechnology 2021, DOI : 10.1186/s12951-021-00994-2.
[50]
P. Klemm, M. Behnke, J. I. Solomun, C. Bonduelle, S. Lecommandoux, A. Traeger, S. Schubert, “Self-assembled PEGylated Amphiphilic Polypeptides for Gene Transfection”, J. Mater. Chem. B, 2021, DOI: 10.1039/D1TB01495A
[49]
F. Hausig, F. H. Sobotta, F. Richter, D. O. Harz, A. Traeger, J. C. Brendel, “Correlation between Protonation of Tailor-Made Polypiperazines and Endosomal Escape for Cytosolic Protein Delivery”, ACS Appl. Mater. Interfaces 2021, DOI: 10.1021/acsami.1c00829
[48]
F. Richter, P. Mapfumo, L. Martin, J. I. Solomun, F. Hausig, J. J. Frietsch, T. Ernst, S. Hoeppener, J. C. Brendel, A. Traeger, “Improved Gene Delivery to K-562 Leukemia Cells by Lipoic Acid Modified Block Copolymer Micelles”, J. Nanobiotechnology 2021, 19, 70
[47]
J. I. Solomun, G. Cinar, P. Mapfumo, F. Richter, E. Moek, F. Hausig, L. Martin, S. Hoeppener, I. Nischang, A. Traeger, “Solely Aqueous Formulation of Hydrophobic Cationic Polymers for Efficient Gene Delivery”, Int. J. Pharm. 2021, 593, 120080
[46]
B. Shkodra, A. T. Press, A. Vollrath, I. Nischang, S. Schubert, S. Hoeppener, D. Haas, C. Enzensperger, M. Lehmann, P. Babic, K. J. Benecke, A. Traeger, M. Bauer, U. S. Schubert, “Formulation of Liver-Specific PLGA-DY-635 Nanoparticles Loaded with the Protein Kinase C Inhibitor Bisindolylmaleimide I”, Pharmaceutics 2020, 12, 1110.
[45]
Richter, L. Martin, K. Leer, E. Moek, F. Hausig, J. C. Brendel, A. Traeger, “Tuning of Endosomal Escape and Gene Expression by Functional Groups, Molecular Weight and Transfection Medium: A Structure–Activity Relationship Study“, J. Mat. Chem. B 2020, 8, 5026-5041.
[44]
C. Chen, F. Richter, C. Guerrero-Sanchez, A. Traeger, U. S. Schubert, A. Feng, S. H. Thang, “Cell-Penetrating, Peptide-Based Raft Agent for Constructing Penetration Enhancers“, ACS Macro Lett. 2020, 260-265.
[43]
A. Traeger, S. Voelker, B. Shkodra-Pula, C. Kretzer, S. Schubert, M. Gottschaldt, U. S. Schubert, O. Werz, “Improved Bioactivity of the Natural Product 5-Lipoxygenase Inhibitor Hyperforin by Encapsulation into Polymeric Nanoparticles“, Mol. Pharm. 2020, 17, 810-816.
[42]
B. Shkodra-Pula, C. Grune, A. Traeger, A. Vollrath, S. Schubert, D. Fischer, U. S. Schubert, “Effect of Surfactant on the Size and Stability of Plga Nanoparticles Encapsulating a Protein Kinase C Inhibitor“, Int. J. Pharm. 2019, 566, 756-764.
[41]
A.-K. Trützschler, T. Bus, M. Sahn, A. Traeger, C. Weber, U. S. Schubert, “The Power of Shielding: Low Toxicity and High Transfection Performance of Cationic Graft Copolymers Containing Poly(2-Oxazoline) Side Chains“, Biomacromolecules 2018, 19, 2759-2771.
[40]
A.-K. Trützschler, T. Bus, M. Reifarth, J. C. Brendel, S. Hoeppener, A. Traeger, U. S. Schubert, “Beyond Gene Transfection with Methacrylate-Based Polyplexes—the Influence of the Amino Substitution Pattern“, Bioconjug. Chem. 2018, 29, 2181-2194
[39]
M. N. Leiske, F. H. Sobotta, F. Richter, S. Hoeppener, J. C. Brendel, A. Traeger, U. S. Schubert, “How to Tune the Gene Delivery and Biocompatibility of Poly(2-(4-Aminobutyl)-2-Oxazoline) by Self- and Coassembly“, Biomacromolecules 2018, 19, 748-760.
[38]
D. Hertz, M. N. Leiske, T. Wloka, A. Traeger, M. Hartlieb, M. M. Kessels, S. Schubert, B. Qualmann, U. S. Schubert, “Comparison of Random and Gradient Amino Functionalized Poly(2-Oxazoline)S: Can the Transfection Efficiency Be Tuned by the Macromolecular Structure?“, J. Polym. Sci. Pol. Chem. 2018, 56, 1210-1224.
[37]
C. Englert, I. Nischang, C. Bader, P. Borchers, J. Alex, M. Pröhl, M. Hentschel, M. Hartlieb, A. Traeger, G. Pohnert, S. Schubert, M. Gottschaldt, U. S. Schubert, “Lichtgesteuerte Freisetzung Von Chemikalien Aus Polymeren Nano- Und Mikropartikelbehältern“, Angew. Chem. 2018, 130, 2504-2508.
[36]
C. Englert, I. Nischang, C. Bader, P. Borchers, J. Alex, M. Prohl, M. Hentschel, M. Hartlieb, A. Traeger, G. Pohnert, S. Schubert, M. Gottschaldt, U. S. Schubert, “Photocontrolled Release of Chemicals from Nano- and Microparticle Containers“, Angew. Chem. Int. Ed. Engl. 2018, 57, 2479-2482.
[35]
T. Bus, A. Traeger, U. S. Schubert, “The Great Escape: How Cationic Polyplexes Overcome the Endosomal Barrier“, Journal of Materials Chemistry B 2018, 6, 6904-6918.
[34]
T. Yildirim, A. Traeger, P. Sungur, S. Hoeppener, C. Kellner, I. Yildirim, D. Pretzel, S. Schubert, U. S. Schubert, “Polymersomes with Endosomal pH-Induced Vesicle-to-Micelle Morphology Transition and a Potential Application for Controlled Doxorubicin Delivery“, Biomacromolecules 2017, 18, 3280-3290.
[33]
M. Prohl, P. D. Moser, J. A. Czaplewska, P. Hoffmann, T. Bus, A. Traeger, H. Goerls, U. S. Schubert, M. Gottschaldt, “Synthesis of D-Fructose Conjugated Ligands Via C6 and C1 and Their Corresponding [Ru(Bpy)2(L)]Cl2 Complexes“, Carbohydr. Res. 2017, 446-447, 19-27.
[32]
I. Perevyazko, A.-K. Trützschler, A. Gubarev, E. Lebedeva, A. Traeger, N. Tsvetkov, U. S. Schubert, “Absolute Characteristics and Conformation of Cationic Polymers by Hydrodynamic Approaches: Poly(AEMA-co-MAEMA-co-DMAEMA)stat Copolymers“, Eur. Polym. J. 2017, 97, 347-355.
[31]
I. Perevyazko, A.-K. Trützschler, A. Gubarev, E. Lebedeva, A. Traeger, U. S. Schubert, N. Tsvetkov, “Molecular and Structural Analysis Via Hydrodynamic Methods: Cationic Poly(2-Aminoethyl-Methacrylate)s“, Polymer 2017, 131, 252-262.
[30]
M. N. Leiske, A.-K. Trutzschler, S. Armoneit, P. Sungur, S. Hoeppener, M. Lehmann, A. Traeger, U. S. Schubert, “Mission Impoxable - or the Unknown Utilization of Non-Toxic Poly(2-Oxazoline)S as Cryoprotectants and Surfactants at the Same Time“, J. Mater. Chem. B 2017.
[29]
C. Englert, M. Prohl, J. A. Czaplewska, C. Fritzsche, E. Preussger, U. S. Schubert, A. Traeger, M. Gottschaldt, “D-Fructose-Decorated Poly(Ethylene Imine) for Human Breast Cancer Cell Targeting“, Macromol. Biosci. 2017, 17.
[28]
T. Bus, C. Englert, M. Reifarth, P. Borchers, M. Hartlieb, A. Vollrath, S. Hoeppener, A. Traeger, U. S. Schubert, “3rd Generation Poly(Ethylene Imine)S for Gene Delivery“, J. Mater. Chem. B 2017, 5, 1258-1274.
[27]
T. Yildirim, A. Traeger, E. Preussger, S. Stumpf, C. Fritzsche, S. Hoeppener, S. Schubert, U. S. Schubert, “Dual Responsive Nanoparticles from a Raft Copolymer Library for the Controlled Delivery of Doxorubicin“, Macromolecules 2016, 49, 3856-3868.
[26]
I. Yildirim, T. Bus, M. Sahn, T. Yildirim, D. Kalden, S. Hoeppener, A. Traeger, M. Westerhausen, C. Weber, U. S. Schubert, “Fluorescent Amphiphilic Heterografted Comb Polymers Comprising Biocompatible PLA and PEtOx Side Chains“, Polym. Chem. 2016, 7, 6064-6074.
[25]
M. Pröhl, T. Bus, J. A. Czaplewska, A. Traeger, M. Deicke, H. Weiss, W. Weigand, U. S. Schubert, M. Gottschaldt, “Synthesis and in Vitro Toxicity of D-Glucose and D-Fructose Conjugated Curcumin–Ruthenium Complexes“, Eur. J. Inorg. Chem. 2016, 2016, 5197-5204.
[24]
C. Englert, A. K. Trutzschler, M. Raasch, T. Bus, P. Borchers, A. S. Mosig, A. Traeger, U. S. Schubert, “Crossing the Blood-Brain Barrier: Glutathione-Conjugated Poly(Ethylene Imine) for Gene Delivery“, J. Control. Release 2016, 241, 1-14.
[23]
T. Yildirim, A. C. Rinkenauer, C. Weber, A. Traeger, S. Schubert, U. S. Schubert, “RAFT Made Methacrylate Copolymers for Reversible pH-Responsive Nanoparticles“, J. Polym. Sci. A 2015, 53, 2711-2721.
[22]
M. Wagner, C. Pietsch, A. Kerth, A. Traeger, U. S. Schubert, “Physicochemical Characterization of the Thermo-Induced Self-Assembly of Thermo-Responsive PDMAEMA-b-PDEGMA Copolymers“, J. Polym. Sci. A 2015, 53, 924-935.
[21]
A. C. Rinkenauer, L. Tauhardt, F. Wendler, K. Kempe, M. Gottschaldt, A. Traeger, U. S. Schubert, “A Cationic Poly(2-Oxazoline) with High in vitro Transfection Efficiency Identified by a Library Approach“, Macromol. Biosci. 2015, 15, 414-425.
[20]
A. C. Rinkenauer, S. Schubert, A. Traeger, U. S. Schubert, “The Influence of Polymer Architecture on in vitro pDNA Transfection“, J. Mater. Chem. B 2015, 3, 7477-7493.
[19]
A. C. Rinkenauer, A. T. Press, M. Raasch, C. Pietsch, S. Schweizer, S. Schworer, K. L. Rudolph, A. Mosig, M. Bauer, A. Traeger, U. S. Schubert, “Comparison of the Uptake of Methacrylate-Based Nanoparticles in Static and Dynamic in vitro Systems as Well as in vivo“, J. Control. Release 2015, 216, 158-168.
[18]
M. Wagner, C. Pietsch, L. Tauhardt, A. Schallon, U. S. Schubert, “Characterization of Cationic Polymers by Asymmetric Flow Field-Flow Fractionation and Multi-Angle Light Scattering-a Comparison with Traditional Techniques“, J. Chromatogr. A 2014, 1325, 195-203.
[17]
M. Wagner, S. Holzschuh, A. Traeger, A. Fahr, U. S. Schubert, “Asymmetric Flow Field-Flow Fractionation in the Field of Nanomedicine“, Anal. Chem. 2014, 86, 5201-5210.
[16]
M. Wagner, M. J. Barthel, R. R. A. Freund, S. Hoeppener, A. Traeger, F. H. Schacher, U. S. Schubert, “Solution Self-Assembly of Poly(Ethylene Oxide)-Block-Poly(Furfuryl Glycidyl Ether)-Block-Poly(Allyl Glycidyl Ether) Based Triblock Terpolymers: A Field-Flow Fractionation Study“, Polym. Chem. 2014, 5, 6943-6956.
[15]
A. T. Press, A. Traeger, C. Pietsch, A. Mosig, M. Wagner, M. G. Clemens, N. Jbeily, N. Koch, M. Gottschaldt, N. Beziere, V. Ermolayev, V. Ntziachristos, J. Popp, M. M. Kessels, B. Qualmann, U. S. Schubert, M. Bauer, “Cell Type-Specific Delivery of Short Interfering Rnas by Dye-Functionalised Theranostic Nanoparticles“, Nat. Commun. 2014, 5, 5565.
[14]
M. J. Barthel, A. C. Rinkenauer, M. Wagner, U. Mansfeld, S. Hoeppener, J. A. Czaplewska, M. Gottschaldt, A. Trager, F. H. Schacher, U. S. Schubert, “Small but Powerful: Co-Assembly of Polyether-Based Triblock Terpolymers into Sub-30 nm Micelles and Synergistic Effects on Cellular Interactions“, Biomacromolecules 2014, 15, 2426-2439.
[13]
M. Wagner, A. C. Rinkenauer, A. Schallon, U. S. Schubert, “Opposites Attract: Influence of the Molar Mass of Branched Poly(Ethylene Imine) on Biophysical Characteristics of siRNA-Based Polyplexese“, RSC Adv. 2013, 3, 12774-12785.
[12]
A. Vollrath, A. Schallon, C. Pietsch, S. Schubert, T. Nomoto, Y. Matsumoto, K. Kataoka, U. S. Schubert, “A Toolbox of Differently Sized and Labeled PMMA Nanoparticles for Cellular Uptake Investigations“, Soft Matter 2013, 9, 99-108.
[11]
A. C. Rinkenauer, A. Vollrath, A. Schallon, L. Tauhardt, K. Kempe, S. Schubert, D. Fischer, U. S. Schubert, “Parallel Hightthroughput Screening of Polymer Vectors for Nonviral Gene Delivery: Evaluation of Structure–Property Relationships of Transfection“, ACS Comb. Sci. 2013, 15, 475-482.
[10]
A. C. Rinkenauer, A. Schallon, U. Günther, M. Wagner, E. Betthausen, U. S. Schubert, F. H. Schacher, “A Paradigm Change: Efficient Transfection of Human Leukemia Cells by Stimuli-Responsive Multicompartment Micelles“, ACS Nano 2013, 7, 9621-9631.
[9]
K. Knop, D. Pretzel, A. Urbanek, T. Rudolph, D. H. Scharf, A. Schallon, M. Wagner, S. Schubert, M. Kiehntopf, A. A. Brakhage, F. H. Schacher, U. S. Schubert, “Star-Shaped Drug Carriers for Doxorubicin with POEGMA and POEtOxMA Brush-Like Shells: A Structural, Physical, and Biological Comparison“, Biomacromolecules 2013, 14, 2536-2548.
[8]
A. Schallon, C. V. Synatschke, V. Jerome, A. H. E. Müller, R. Freitag, “Nanoparticulate Nonviral Agent for the Effective Delivery of pDNA and siRNA to Cifferentiated Cells and Primary Human T Lymphocytes“, Biomacromolecules 2012, 13, 3463-3474.
[7]
A. P. Majewski, A. Schallon, V. Jerome, R. Freitag, A. H. E. Müller, H. Schmalz, “Dual-Responsive Magnetic Core-Shell Nanoparticles for Nonviral Gene Delivery and Cell Separation“, Biomacromolecules 2012, 13, 857-866.
[6]
C. V. Synatschke, A. Schallon, V. Jerome, R. Freitag, A. H. E. Müller, “Influence of Polymer Architecture and Molecular Weight of Poly(2-(Dimethylamino)Ethyl Methacrylate) Polycations on Transfection Efficiency and Cell Viability in Gene Delivery“, Biomacromolecules 2011, 12, 4247-4255.
[5]
A. Schallon, C. V. Synatschke, D. V. Pergushov, V. Jerome, A. H. E. Müller, R. Freitag, “DNA Melting Temperature Assay for Assessing the Stability of DNA Polyplexes Tntended for Nonviral Gene Delivery“, Langmuir 2011, 27, 12042-12051.
[4]
A. Pfaff, A. Schallon, T. M. Ruhland, A. P. Majewski, H. Schmalz, R. Freitag, A. H. E. Müller, “Magnetic and Fluorescent Glycopolymer Hybrid Nanoparticles for Intranuclear Optical Imaging“, Biomacromolecules 2011, 12, 3805-3811.
[3]
A. Schallon, V. Jerome, A. Walther, C. V. Synatschke, A. H. E. Müller, R. Freitag, “Performance of Three PDMAEMA-Based Polycation Architectures as Gene Delivery Agents in Comparison to Linear and Branched PEI“, React. Funct. Polym. 2010, 70, 1-10.
[2]
M. Müllner, A. Schallon, A. Walther, R. Freitag, A. H. E. Müller, “Clickable, Biocompatible, and Fluorescent Hybrid Nanoparticles for Intracellular Delivery and Optical Imaging“, Biomacromolecules 2010, 11, 390-396.
[1]
V. Jerome, A. Heider, A. Schallon, R. Freitag, “Exhaustive in Vivo Labelling of Plasmid DNA with BrdU for Intracellular Detection in Non-Viral Transfection of Mammalian Cells“, Biotechnol. J. 2009, 4, 1479-1487.
